Radiation Therapy as Primary and Adjuvant Treatment for Local and Regional Melanoma

Lawrence B. Berk, MD, PhD


Cancer Control. 2008;15(3):233-238. 

In This Article

Radiobiology of Melanoma: In Vitro and In Vivo Studies

Several preclinical studies investigated the radiosensitivity of melanoma. Cell culture studies showed that melanomas have a wide range of sensitivity to radiation, as do other cell lines.[1,2] Spheroid studies confirmed the cell culture studies.[3,4] The radiation sensitivity of human xenografts varied from sensitive to resistant.[4,5] The alpha:beta ratio from cell culture measurements correlated with the 2-Gy survival fraction (SF2) from in vivo measurements, confirming that there are innate differences in the radiobiology of melanoma cells.[6] In vivo studies also showed that sublethal doses of radiation therapy increased the subsequent risk of metastases, possibly due to increased hypoxia in the regrowing primary tumor.[7] In vitro studies also suggest that compared with primary lesions, cells from metastatic lesions are more radioresistant.[8]


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: