Radiation Therapy as Primary and Adjuvant Treatment for Local and Regional Melanoma

Lawrence B. Berk, MD, PhD

Disclosures

Cancer Control. 2008;15(3):233-238. 

In This Article

Radiobiology of Melanoma: In Vitro and In Vivo Studies

Several preclinical studies investigated the radiosensitivity of melanoma. Cell culture studies showed that melanomas have a wide range of sensitivity to radiation, as do other cell lines.[1,2] Spheroid studies confirmed the cell culture studies.[3,4] The radiation sensitivity of human xenografts varied from sensitive to resistant.[4,5] The alpha:beta ratio from cell culture measurements correlated with the 2-Gy survival fraction (SF2) from in vivo measurements, confirming that there are innate differences in the radiobiology of melanoma cells.[6] In vivo studies also showed that sublethal doses of radiation therapy increased the subsequent risk of metastases, possibly due to increased hypoxia in the regrowing primary tumor.[7] In vitro studies also suggest that compared with primary lesions, cells from metastatic lesions are more radioresistant.[8]

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