Perioperative Celebrex Administration for Pain Management After Total Knee Arthroplasty — A Randomized, Controlled Study

Yu-Min Huang; Chiu-Meng Wang; Chen-Ti Wang; Wei-Peng Lin; Lih-Ching Horng; Ching-Chuan Jiang

BMC Musculoskelet Disord

Conclusion

Perioperative celecoxib, combined with opioids, is an effective and safe regimen for pain control in TKA patients. Perioperative celecoxib can significantly decrease postoperative pain scores at rest and opioid use, while improving postoperative ROM results for TKA surgeries. Considering the benefits, we suggest celecoxib for multimodal analgesia.

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Acknowledgments

We thank the patients who participated in this study and the staff involved in this work. The study was supported by a research fund from the National Taiwan University & Hospital.

Reprint Address

Ching-Chuan Jiang, Department of Orthopaedic Surgery, National Taiwan University Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan. E-Mail: ccj@ntu.edu.tw

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this: Perioperative Celebrex Administration for Pain Management After Total Knee Arthroplasty — A Randomized, Controlled Study - Medscape - Jun 03, 2008.

Table 1. Patient Demographics and Surgical Data.
There were no significant differences between these groups.
Group	Age (yr)	Pre-OP ROM (degrees)	Pre-OP VAS	Surgery Duration (min)	Tourniquet Duration (min)	Intra-operative blood loss (ml)
Control	70 ± 7	118 ± 17	4.7 ± 1.9	75 ± 17	45 ± 13	177 ± 54
Celecoxib	70 ± 7	116 ± 18	5.1 ± 1.7	77 ± 17	46 ± 17	181 ± 63

Huang et al. BMC Musculoskeletal Disorders 2008 9:77 doi:10.1186/1471-2474-9-77

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