Impact of Tobacco Smoking and Smoking Cessation on Cardiovascular Risk and Disease

Christopher Bullen


Expert Rev Cardiovasc Ther. 2008;6(6):883-895. 

In This Article

Coronary Heart Disease

As noted, there is a threefold increase in the odds of having a nonfatal AMI in current smokers compared with nonsmokers, and an increased risk of sudden cardiac death. The INTERHEART study investigators found an OR of a nonfatal AMI in current smokers compared with nonsmokers of 2.95 (95% CI: 2.77–3.14).[10] In the British Regional Heart Study, Wannamethee et al. followed 7735 British men, aged 40–59 years, over 8 years and found that current smokers had more than double the risk of sudden cardiac death compared with nonsmokers (RR: 2.3; 95% CI: 1.2–4.0).[20] Hasdai et al. followed-up 6600 patients who underwent percutaneous coronary revascularization from 1979 to 1995 for up to 16 years and found that current smokers had twice the risk of Q-wave infarction than nonsmokers (RR: 2.08; 95% CI: 1.16–3.72).[21]


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