Cigarette Smoking and IVF

Sérgio R. Soares; Marco A. Melo


Expert Rev of Obstet Gynecol. 2008;3(4):555-563. 

In This Article

Abstract and Introduction


The goal of this article is to present a thorough review of the literature concerning the relationship between cigarette smoking and IVF cycle outcome, as well as the possible mechanisms through which tobacco constituents affect these cycles. Cigarette smoke affects spermatozoa structure and function; sperm DNA is damaged by tobacco compounds. Spermatozoa from smokers have reduced fertilizing capacity and embryos display lower implantation rates. Ovarian aging is accelerated in smokers and oocyte number and maturation are negatively affected by cigarette smoke. Clinical parameters of IVF cycle outcome are worse in female smokers. This is also the consequence of impaired uterine receptiveness.


Cigarette smoking has been reported to affect reproductive function in many ways.[1] Some of these effects may impair the likelihood of spontaneous pregnancy, while some others may even hamper IVF success probability.[1] This text focuses on the possible mechanisms through which cigarette smoking may interfere with IVF cycle outcome.


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