Precautions and Drug Interactions
Although no specific data are available, precautions that are inherent to the cephalosporin class would still apply. These precautions would be in patients with a hypersensitivity to penicillin, in pregnant and breast-feeding women, in patients younger than 18 years of age, and in patients with renal impairment or severe hepatic impairment. As with all antibiotics that affect normal gastrointestinal flora, ceftobiprole may increase the risk for C. difficile infection and possibly increase the international normalized ratio in patients taking warfarin. Possible drug interactions are with warfarin and other drugs that may alter the elimination of ceftobiprole, creating an environment of toxicity.
The Annals of Pharmacotherapy. 2008;42(6):806-816. © 2008 Harvey Whitney Books Company
Cite this: Ceftobiprole: An Extended-Spectrum Anti–Methicillin-Resistant Staphylococcus aureus Cephalosporin - Medscape - Jun 01, 2008.