Ceftobiprole: An Extended-Spectrum Anti–Methicillin-Resistant Staphylococcus aureus Cephalosporin

Shawn D Anderson, PharmD; John G Gums, PharmD, FCCP


The Annals of Pharmacotherapy. 2008;42(6):806-816. 

In This Article

Precautions and Drug Interactions

Although no specific data are available, precautions that are inherent to the cephalosporin class would still apply. These precautions would be in patients with a hypersensitivity to penicillin, in pregnant and breast-feeding women, in patients younger than 18 years of age, and in patients with renal impairment or severe hepatic impairment. As with all antibiotics that affect normal gastrointestinal flora, ceftobiprole may increase the risk for C. difficile infection and possibly increase the international normalized ratio in patients taking warfarin. Possible drug interactions are with warfarin and other drugs that may alter the elimination of ceftobiprole, creating an environment of toxicity.


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