Acinetobacter baumannii: An Emerging Multidrug-resistant Threat

Thomas D Gootz; Andrea Marra


Expert Rev Anti Infect Ther. 2008;6(3):309-325. 

In This Article

Overview of Antibiotic-resistance Mechanisms in

As with all other nonfermentative, Gram-negative bacilli, A. baumannii can develop clinical resistance to all classes of antimicrobials. Since is is largely a nosocomial pathogen, A. baumannii is bombarded by the selective pressure of a broad variety of antibiotics. An overview of the intrinsic and acquired mechanisms of antibiotic resistance reported for this organism is provided in Table 1 and Table 2 , respectively. In general, the mechanisms of resistance, and the acquired genetic determinants encoding some of them, have probably come from other nonfermenters in the environment, as well as common members of the Enterobacteriaceae. In addition, A. baumannii has a number of intrinsic mechanisms, including ß-lactamases and efflux pumps, which contribute to resistance.


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