Quantum Dots for Cancer Diagnosis and Therapy: Biological and Clinical Perspectives

Hua Zhang; Douglas Yee; Chun Wang


Nanomedicine. 2008;3(1):83-91. 

In This Article


The rapid development of QD technology has already fulfilled some of the hopes of developing new, more effective cancer-imaging probes. First, stable encapsulation of QDs with amphiphilic polymers has prevented the quenching of QD fluorescence in the aqueous in vivo environment. Second, QDs are relatively inert and stable. Finally, successful conjugation of QDs with biomolecules has made active targeting to tumors possible. Despite their promise and success so far in cancer imaging, there are challenges in enhancing sensitivity, maximizing specificity and minimizing toxicity of QDs, which must be tackled before clinical applications can proceed.


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