Ovarian Hyperstimulation Syndrome Caused by an FSH-Secreting Pituitary Adenoma

Odelia Cooper; Jordan L Geller; Shlomo Melmed


Nat Clin Pract Endocrinol Metab. 2008;4(4):234-238. 

In This Article

Differential Diagnosis

OHSS can occur in association with other disease states. Patients with polycystic ovary syndrome who become pregnant are at risk of OHSS as they have multiple partially stimulated antral follicles, which can over-respond to exogenous gonadotropins as reported during assisted reproductive treatment. OHSS has also been reported in association with primary hypothyroidism, possibly caused by TSH-mediated stimulation of the FSH receptor or by enhanced TRH production stimulating gonadotropin release. In addition, a single patient with bilateral granulosa cell tumors has been reported to have developed OHSS.[14]


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