All patients presenting for patch testing at NACDG patch test sites were eligible for inclusion. During this time interval (1992-2004), our method of testing was unchanged although NACDG membership varied as some members left and others were added. Patients were patch-tested as described previously. Finn Chambers (Epitest Ltd Oy, Tuusula, Finland) on Scanpor tape (Norgesplaster Aksjeselskap, Vennesla, Norway) were used to apply allergens from Chemotechnique Diagnostics AB (Malmö, Sweden). The patches were applied for 2 days, removed and interpreted, and reinterpreted 1 to 5 days later. Patch tests results were scored as positive if + or greater. Macular erythema was scored as doubtful and was not included in this analysis. The concentration of nickel sulfate (2.5% in petrolatum) was consistent from 1992 to 2004.
De-identified data from participating centers were sent to a central database, manually entered, and checked for consistency. All analyses were performed with SAS (Statistical Analysis System, SAS Institute Inc., Cary, NC). Pearson chi-square tests were used to examine the association between nickel sensitivity and time period, gender, or age. A significance level of .05 was used.
Dermatitis. 2008;19(1):16-19. © 2008 American Contact Dermatitis Society
Cite this: Detection of Nickel Sensitivity Has Increased in North American Patch-Test Patients - Medscape - Feb 01, 2008.