Novel Agents for Intractable Itch

C. B. Lynde; J. N. Kraft, MD; C. W. Lynde, MD, FRCPC


Skin Therapy Letter. 2008;13(1):6-9. 

In This Article

Systemic Agents

Systemic agents are tried if there is a specific indication or if the more conservative measures are ineffective. Antihistamines are predominantly used for treating urticaria, but are otherwise rarely effective for itch. The first generation antihistamines are sedating, but are generally considered to be the most effective when compared with its subsequent counterparts. Due to its potential to affect performance, sedating antihistamines should be administered at night. The addition of successive generations (second or third) may be helpful for daytime relief as they are minimally sedating. Tranquilizers have been used, but they only serve to sedate the patient and do not directly address the pruritic symptoms.


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