We found no clinically meaningful evidence for an increased risk of ESRD associated with use of phenacetin-free analgesics in single or combined formulation. The apparent risk increase shown in a small subgroup with extreme lifetime dose of analgesics is most likely an indirect, non-causal association. This hypothesis, however, cannot be confirmed or refuted within our case-control study. Overall, our results lend support to the mounting evidence that phenacetin-free analgesics do not induce ESRD and that the notion of "analgesic nephropathy" needs to be re-evaluated.
The pre-publication history for this paper can be accessed here: https://www.biomedcentral.com/1471-2369/8/15/prepub
The research project was accompanied and the study scientifically governed by an independent Scientific Advisory Committee of distinguished experts of international reputation:
Prof. A. R. Feinstein, Yale University, New Haven, USA (Chairman until end 2001, deceased)
Prof. K.M. Koch, University Hannover, Germany (chairman from 2002)
Prof. S. Shapiro, Columbia University USA, CapeTown University South Africa
Prof. P. Bauer, University Viena, Austria
Prof. E. Delzell, University Birmingham, USA
Dr. G. Curhan, Havard Boston, USA (until 2004)
Prof. J.M. Fox, University Saarland, Germany
Prof. P. Michielsen, University Leuven, Belgium
Prof. S. Suissa, University Montreal, Canada
Prof. B. Kasiske, University Minneapolis, USA (from 2002)
Prof. M. Mihatsch, University Basel, Switzerland
We thank the Nephrological Associations from Germany and Austria for their support to make the study feasible: Oesterreichische Gesellschaft für Nephrologie, Deutsche Gesellschaft für Nephrologie, Deutsche Dialysegesellschaft niedergelassener Ärzte e.V., Deutsche Arbeitsgemeinschaft fuer Klinische Nephrologie. We also like to thank the representatives of the German Drug Authority BfArM, Dr. A. Thiele and Dr. K. Menges, for their continuous support and particular their critical review in all phases of the study. We are also grateful for the support coming from the representatives of the Steering Committee of the sponsoring companies, Dr. B. Aicher and Dr. T. Schettler.
We thank all members of the Steering Committee, co-workers of the coordinating centres in Mannheim, Berlin, and Vienna as well as all 170 collaborating dialysis centres, which are completely listed in the study website and published in the methods paper.
Lothar AJ Heinemann, Centre for Epidemiology & Health Research Berlin, Invalidenstr. 115, 10115 Berlin, Germany; Email: email@example.com
BMC Nephrology © 2007 van der Woude et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this: Analgesics Use And ESRD In Younger Age: A Case-control Study - Medscape - Dec 05, 2007.