A Reader Responds to "Fat Reduction by Topical Waist Applications May Actually Work"

Ayaz Virji, MD, FAAFP


Medscape J Med. 2008;10(4):84 

To the Editor,

Aminophylline is a methylxanthine inhibitor and has a beta- mimetic effect on adipocytes. B3 receptors on adipocytes are lipolytic when stimulated. So, the mechanism of action makes sense. Aminophylline is a common compound found in many mesotherapy formulas for spot fat reduction. A similar article was published by Greenway and Bray in the 1980s showing similar results on women's thighs.[1] Be cautious, though: There is no panacea for obesity. The cream, like the aminophylline found in mesotherapy lipodissolve, will only work on subcutaneous fat, not the dangerous visceral fat responsible for escalating risk for CAD [coronary artery disease], diabetes, and cancer. Aminophylline may be useful for body contouring for people with a BMI [body mass index] of 30 or less, but in no way should be considered a weight loss treatment.[2]

Ayaz Virji, MD, FAAFP
Board Certified, Family Medicine
Board Certified, Bariatric Medicine
Board Certified, Amer Board Phys Nutr Specialists


  1. Greenway FL, Bray GA, Heber D. Topical fat reduction. Obes Res. 1995;3:561S-568S. Abstract

  2. Lundberg GD. Fat reduction by topical waist applications may actually work. Medscape J Med. 2008;10:43. Available at: http://www.medscape.com/viewarticle/569956 Accessed March 31, 2008.

Editor's Note:

This letter was shown to the author who has chosen not to reply.


Reader Comments on: Fat Reduction by Topical Waist Applications May Actually Work
See reader comments on this article and provide your own.

Readers are encouraged to respond to George Lundberg, MD, Editor in Chief of The Medscape Journal of Medicine, for the editor's eyes only or for possible publication as an actual Letter in the Medscape Journal via email: glundberg@medscape.net


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: