Metastasis: A Therapeutic Target for Cancer

Patricia S Steeg; Dan Theodorescu


Nat Clin Pract Oncol. 2008;5(4):206-219. 

In This Article


It is time for agents that target metastasis and, in particular, metastatic colonization, to enter mainstream clinical development and testing. We hypothesize that the addition of these targets to the current armamentarium will ultimately enhance the efficacy of current treatment regimens. There is a lot of work remaining, including the selection of optimum drug combinations and the optimization of multiple aspects of trial design. In addition, we must garner the willpower to conduct adjuvant trials when fantastic objective response rates are not seen in the metastatic setting -- it can be done.

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