Use of Clindamycin in Pediatric Infections

Marcia L. Buck, Pharm.D., FCCP

Disclosures

Pediatr Pharm. 2008;14(2) 

In This Article

Dosing Recommendations

The parenteral dose for clindamycin in children is 20 to 40 mg/kg/day divided and given IV or IM every 6 or 8 hours. In neonates, the dose should be based on both weight and age, to allow for a slower elimination. In preterm neonates less than 2 kg, a dose of 10 mg/kg/day should be divided and given every 12 hours. In neonates over 2 kg and less than 1 week of age, a dose of 15 mg/kg/day should be divided and given every 8 hours. In older neonates, a dose of 20-30 mg/kg/day may be divided and given every 6 to 8 hours.[2,3]

The recommended adult dose for parenteral clindamycin is 600 to 1,200 mg/day divided and given IV or IM every 12, 8, or 6 hours. The maximum concentration for IV administration is 18 mg/mL, and the maximum rate of infusion is 30 mg/min.[2,3]

The recommended oral dose of clindamycin in children with serious infections is 8 to 16 mg/kg/day divided and given every 6 or 8 hours. In those with more severe infections, a higher dose of 16 to 20 mg/kg/day may be used. In adults, the manufacturer recommends an oral dose of 150 mg to 300 mg every 6 hours for serious infections and a dose of 300 to 450 mg every 6 hours for severe infections. Clindamycin capsules should be taken with a full glass of water to prevent esophagitis.[2,3]

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