Use of Clindamycin in Pediatric Infections

Marcia L. Buck, Pharm.D., FCCP

Disclosures

Pediatr Pharm. 2008;14(2) 

In This Article

Pharmacokinetics

Clindamycin is available in three salt forms: hydrochloride (oral capsules), palmitate (oral solution), and phosphate (injection). Clindamycin hydrochloride is well absorbed after oral administration, with an absolute bioavailability of 90%. In adults given a standard 150 mg oral dose, an average peak serum clindamycin level of 2.5 mcg/mL is achieved within 45 minutes. Administration with food does not appear to affect absorption.

Clindamycin is widely distributed in body fluids and tissues, including bone and pleural fluid. It does not appreciably distribute into cerebrospinal fluid, even with inflamed meninges. It is extensively metabolized via cytochrome P450 3A4 to primarily inactive compounds, with approximately 10% excreted in the urine. The average half-life in adults is 2 to 3 hours. The serum half-life may be slightly longer in patients with severe renal or hepatic dysfunction, but no specific dosing adjustment is recommended.[1,2,3] The half-life is also longer in neonates: approximately 4 hours in term neonates and up to 8 to 9 hours in preterm neonates.[16]

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