Use of Risperidone in Children With Autism, Bipolar Disease, or Schizophrenia

Marcia L. Buck, Pharm.D., FCCP

Pediatr Pharm. 2008;14(1) 

In This Article

Mechanism of Action

As with other antipsychotics, the exact mechanism of action for risperidone is not fully understood. Therapeutic effects are thought to result from risperidone's combined antagonist activity at dopamine type 2 (D2) and serotonin type 2 (5HT2) receptors. In addition to having high affinity for these receptors, risperidone also has antagonist activity at α1 and α2-adrenergic and histaminergic (H1) receptors. It has low to moderate affinity for serotonin 5HT1C, 5HT1D, and 5HT1A receptors, weak affinity for dopamine D1 and haloperidol-sensitive sigma site receptors, and no affinity for cholinergic muscarinic or β-adrenergic receptors.[2,3]

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