Proteomics, Saliva, and Sjögren's Syndrome

Robert I. Fox, MD; Carla M. Fox, RN


February 20, 2008


The article by Peluso is called a "proteomic study."

Perhaps the most available fluid is saliva (or tears), and analysis of these fluids in SS may provide clues to changes in pathogenesis. Certainly the unexpected change in SS saliva may seem modest at first, but it does demonstrate the existence of complicated pathways.

The article also points out several other important, emerging areas of pathogenesis and therapy:

  • The new techniques of proteomics and the role of mucosal immunity may help us retard complications to the eye and mouth/teeth; and

  • The interaction of cytokines, neurokines of the hypothalamic-adrenal axis and estrogen pathway that influences salivation, may provide insight into one of most difficult problems; namely, the chronic fatigue and "brain fog" that accompanies so many autoimmune disorders.

Thus, several exciting studies are being pursued to apply the science of proteonomics and develop new therapies for inflammatory diseases to enhance patient quality of life.



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