Cognitive Dysfunction in MS: Bridging the Gap Between Neurocognitive Deficits, Neuropsychological Batteries and MRI

Erica Grazioli; Ann E Yeh; Ralph HB Benedict; Joy Parrish; Bianca Weinstock-Guttman


Future Neurology. 2008;3(1):49-59. 

In This Article


MS is associated with specific cognitive impairments. More than 50% of patients may present with early cognitive dysfunction. Studies have demonstrated that persons with cognitive impairment are at greater risk for difficulties and conflicts affecting employment, social relationships and activities of daily living.[41,104,105] Therefore, validated cognitive screening tools followed by standardized batteries if screening abnormalities are present should become part of the routine evaluation and monitoring of MS patients. Specific genetic polymorphisms have been found to have an effect on cognitive function in MS and to have a relationship with MRI measures. Therapeutic and psychosocial support should be available for MS patients diagnosed with cognitive dysfunction.


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