Cognitive Dysfunction in MS: Bridging the Gap Between Neurocognitive Deficits, Neuropsychological Batteries and MRI

Erica Grazioli; Ann E Yeh; Ralph HB Benedict; Joy Parrish; Bianca Weinstock-Guttman

Disclosures

Future Neurology. 2008;3(1):49-59. 

In This Article

Cognitive Dysfunction in MS

Between 45 and 60% of MS patients have some level of cognitive impairment,[4,6] and often the cognitive limitations can be identified from early stages of the disease.[7] Although patients with long lasting and advanced physical disability may also have severe cognitive impairment, the correlation between cognitive dysfunction and disease characteristics (type and duration of MS) is usually weak or modest.[4] Possible confounding factors that can interfere with the assessment of cognitive function in general, and in MS patients in particular, are depression (>50% of MS patients are depressed based on screening questionnaires) and both physical and psychological/cognitive fatigability.[8,9] Shorter batteries and specific depression questionnaires (i.e., Beck depression inventory) can help to identify and control for these confounding factors,[10] although the depression inventories themselves may be confounded by fatigue related to physical illness.[11]

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