Genetic Association Studies
Although increasing data pinpoint CTLA4 as a candidate gene, results of association studies did not support certain polymorphisms in CTLA4 being the major susceptibility locus for CD.[14,28,29,32,34,42,43,44] A recent study analyzing all common SNPs in CTLA4 suggested an association on the haplotype level rather than on the single SNP variant level. In Figure 2, the suggested genetic loci of CD are shown.
Genetic loci in CD.
Other studies did not confirm association for promising genes like tTG, FAS, MMP-1 and 3, TCR αßγδ, IL12ß, CD28, CD80, CD86, KIR, LILR, STAT 1, PGPEP1, IRF1, DPPIV, TGM2, NOS2, or IFNγ.
Am J Gastroenterol. 2008;103(1):190-195. © 2008 Blackwell Publishing
Cite this: Genetic Background of Celiac Disease and Its Clinical Implications - Medscape - Jan 01, 2008.