Genetic Background of Celiac Disease and Its Clinical Implications

Victorien M. Wolters, M.D.; Cisca Wijmenga, Ph.D.

Disclosures

Am J Gastroenterol. 2008;103(1):190-195. 

In This Article

Genetic Epidemiology of CD

Multiple lines of evidence favoring a genetic contribution to the pathogenesis of CD have been suggested by epidemiologic data ( Table 1 ). A familial aggregation is found in 5-15% of CD patients and a striking 83-86% concordance rate was observed among monozygotic twin pairs.[19,20] CD incidence and prevalence have been found to vary significantly, depending on geographic location and racial or ethnic background; these differences might be reflected by either genetic or environmental susceptibility factors.[21]

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