Genetic Background of Celiac Disease and Its Clinical Implications

Victorien M. Wolters, M.D.; Cisca Wijmenga, Ph.D.

Disclosures

Am J Gastroenterol. 2008;103(1):190-195. 

In This Article

Clinically Relevant Conclusions

  • Genetic susceptibility is a prerequisite for developing CD, with HLA class II as the most important genetic factor identified so far.

  • The absence of HLA-DQ2/DQ8 can exclude the possibility or future development of CD with a certainty close to 100%.

  • In asymptomatic HLA-DQ2/DQ8 positive first-degree relatives <20 yr old serologic screening is indicated approximately every 5-10 yr. In asymptomatic HLA-DQ2/DQ8 positive first-degree relatives >20 yr old one single screening at the age of approximately 50 yr is indicated, as complications of CD can develop.

  • The presence of HLA-DQ2/DQ8 is clinically irrelevant since 30-40% of the general population is positive for one or both of these factors and only a fraction (0.5-1%) of these individuals has CD.

  • Considerable advances in the genetics of CD will identify more genetic determinants for CD development and disease progression and establish clinically relevant genetic risk profiles. CD might serve as a model for other autoimmune diseases.


CLICK HERE for subscription information about this journal.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....