Genetic Background of Celiac Disease and Its Clinical Implications

Victorien M. Wolters, M.D.; Cisca Wijmenga, Ph.D.


Am J Gastroenterol. 2008;103(1):190-195. 

In This Article

Future Prospects

We assume an etiology model for CD comprising a major gene (HLA) and several low risk genes with a function in the intestinal barrier and immune system. It is therefore important to identify susceptibility genes as well as protective genes in CD.

In the coming years, identifying other target genes and understanding the pathways they influence will lead to a better understanding of CD pathogenesis. Ultimately, we might be able to define genetic risk profiles for more precise diagnoses and for predicting disease progression, and they may lead to novel therapies.


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