Update on Ocular Behcet's Disease

Pelin Atmaca-Sonmez; Leyla S Atmaca; Olcay Tiryaki Aydintug


Expert Rev Ophthalmol. 2007;2(6):957-979. 

In This Article

Abstract and Introduction

Behçet's disease is among the chronic-relapsing, multisystemic inflammatory disorders that ARE characterized by obliterative vasculitis. Although it may affect almost all/any systems or organs, the key clinical manifestations are recurrent oral aphthous ulcers, genital ulcers, uveitis and skin lesions. Although most prevalent along the ancient Silk Route, extending from eastern Asia to the Mediterranean, Behçet's disease is seen worldwide. This article aims to give a brief review on various aspects of Behçet's disease, but particularly ocular involvement, with updated information.

Behçet's disease (BD) is a multisystemic disorder of recurrent acute inflammation. It is named after Hulusi Behçet, a Turkish dermatologist who, in 1937, recognized recurrent oral and genital ulcers and iridocyclitis as a separate clinical entity,[1] although symptoms similar to those of BD were described as early as the time of Hippocrates and later by several others.[2,3] The disease may affect almost all/any systems or organs, including the ocular, pulmonary, gastrointestinal, genitourinary and nervous systems, as well as joints and large vessels. Nevertheless, the major characteristic of the disease is a systemic vasculitis with mucosa, skin and the eyes being predominantly involved.


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