Role of Adaptive Thermogenesis in Unsuccessful Weight-Loss Intervention

Angelo Tremblay; Geneviève Major; Éric Doucet; Paul Trayhurn; Arne Astrup


Future Lipidology. 2007;2(6):651-658. 

In This Article


The observations presented in this paper indicate that greater than predicted decrease in energy expenditure may happen in response to weight loss in obese individuals. The extent to which this may represent a thermogenic defect is debatable, but its ability to interfere with weight loss seems to be much clearer. Furthermore, this paper suggests that such a decrease would not occur randomly since it appears to be, at least partly, the consequence of fluctuations in body pollutants, which are known to produce detrimental effects on health and factors involved in the control of body thermogenesis.


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