Pharmacology and Clinical Efficacy of Erdosteine in Chronic Obstructive Pulmonary Disease

Maurizio Moretti


Expert Rev Resp Med. 2007;1(3):307-316. 

In This Article

Overview of the Market

Mucolytic agents are classified as direct and indirect agents according to their pharmacodynamic activity.[9] Direct agents include thiol compounds, which break the disulfide bridges of mucus glycoproteins by free sulfhydryl groups, and enzymes, such as recombinant human DNAse, which digests extracellular DNA ( Box 1 ). Indirect agents include different molecules that modify mucus secretion by their own mechanism of action ( Box 2 ).


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