CNO includes unifocal and multifocal bone lesions. The latter form is known as CRMO. CRMO and other forms of CNO can evolve into spondyloarthropathy and can involve the skin, eyes, lungs and gastrointestinal tract. NSAIDs are recommended as a first-line therapy; DMARDs, steroids, bisphosphonates and TNF blockers have also been used. Multidisciplinary diagnostic and therapeutic approaches are necessary to cover the clinical variability of CRMO and to ensure that this syndrome is managed effectively.
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The authors particularly thank Dr Margta Rominger, Department of Radiology, Philipps-University Marburg, for performing radiographic studies depicted in Figures 1A and 1B.Reprint Address
Children's Hospital, University of Wuerzburg, Josef-Schneider-Strasse 2, Wuerzburg, 97080, Germany hermann. Email: email@example.com
Nat Clin Pract Rheumatol. 2007;3(12):733-738. © 2007 Nature Publishing Group
Cite this: Chronic Recurrent Multifocal Osteomyelitis: What is it and how Should it be Treated? - Medscape - Nov 01, 2007.