The White Dot Syndromes

Yoko Matsumoto, MD, PHD; Sebastian P. Haen, MD; Richard F. Spaide, MD


Compr Ophthalmol Update. 2007;8(4):179-200. 

In This Article


We described APMPPE, serpiginous choroiditis, birdshot chorioretinopathy, MCP, DSF, PIC, MEWDS, and DUSN as white dot syndromes in this review. The white dot syndromes are rare inflammatory disorders affecting the retina, RPE, and choroid. Not all of these disorders cause white dots, but they have unique lesions in the fundus.

Most of these conditions share an association with systemic infectious diseases. Some of them can be treated with anti-inflammatory agents and/or immunosuppressive drugs. Secondary CNV is common and causes severe loss of vision. In the past, laser photocoagulation had been used for these disorders. Recently, we developed PDT and agents that bind VEGF, which may be able to make the patient's outcome better. Direct thermal laser treatment is the first choice for DUSN.


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