Background: A 41-year-old woman presented to an endocrinology-gynecology clinic having been diagnosed 7 years earlier with polycystic ovarian syndrome on account of hirsutism, subfertility, greasy skin, acne and multiple ovarian cysts. Ovulation induction had led to a successful pregnancy. Subfertility recurred, however, and persisted alongside a new diagnosis of hypertension and progressive weight gain. Upon examination, the patient was hypertensive with facial plethora, rounded facies and violaceous abdominal striae.
Investigations: Low-dose dexamethasone test, bedtime salivary and 24-h urinary free cortisol estimations, CT scan of the abdomen, and serum hormone and gonadotropin analyses.
Diagnosis: Cushing's syndrome due to a right adrenocortical adenoma.
Management: The patient underwent laparoscopic right adrenalectomy, which led to resolution of all symptoms, signs and biochemical abnormalities.
Nat Clin Pract Endocrinol Metab. 2007;3(11):778-783. © 2007
Nature Publishing Group
Cite this: Cushing's Syndrome in Women With Polycystic Ovaries and Hyperandrogenism - Medscape - Nov 01, 2007.