In conclusion, HSCT for SSc has advanced to the stage of two international prospective randomized controlled trials which should determine if this aggressive form of therapy may 'reset' an autoaggressive immune system and benefit patients with severe, poor prognosis SSC. During the past several years the potential use of MSCs as immunomodulating agents is being explored (e.g. in the acute GvHD setting in which a positive effect seems possible with little or no acute toxicity). Preliminary results suggest that bone marrow-derived MSCs from SSc patients exhibit effective in-vitro antiproliferative effects on lymphocytes.
We would like to thank AMGEN and Genzyme for unrestricted research grants and EULAR and the Horton Foundation, Switzerland for part financial support for the ASTIS study. In addition, the SCOT trial is supported by the NIH/NIAMS. Our gratitude also extends to Prof. Jakob Passweg and Dr Chiara Bocelli-Tyndall for gathering the data for the phase I/II studies and Prof. Jakop van Laar and Prof. Dominique Farge for an update on the ASTIS study and the EBMT registry.Abbreviation Notes
ASTIS = Autologous Stem cell Transplantation International Scleroderma; EBMT = European Group for Blood and Marrow Transplantation; EULAR = European League Against Rheumatism; GvHD = graft versus host disease; HSCT = hematopoietic stem cell transplantation; MSC = mesenchymal stem cell; SCOT = Scleroderma Cyclophosphamide Or Transplant; SSc = systemic sclerosis; TRM = transplant-related mortality
Correspondence to Alan Tyndall, Department of Rheumatology Felix Platter Spital, Burgfelderstrasse 101, 4012 Basel, Switzerland Tel: +41 61 326 4003; fax: +41 61 3264010; e-mail: email@example.com
Curr Opin Rheumatol. 2007;19(6):604-610. © 2007 Lippincott Williams & Wilkins
Cite this: Adult Stem Cell Treatment of Scleroderma - Medscape - Nov 01, 2007.