Newer anticoagulants should be used with caution in patients with mild-to-moderate renal impairment. Unfractionated heparin remains the preferred anticoagulant in most patients with severe renal impairment, even though its use is associated with increased bleeding in this population. Dosing of newer anticoagulants, except argatroban, requires cautious dosage reduction and increased monitoring for complications.
Susan L. Roedder, M.D., is acknowledged for her assistance in manuscript preparation.Reprint Address
Correspondence to: Dr. Lobo at Methodist University Hospital, 1265 Union Avenue, Memphis, TN 38104 ( email@example.com ).
Am J Health Syst Pharm. 2007;64(19):2017-2026. © 2007 American Society of Health-System Pharmacists
Cite this: Use of Newer Anticoagulants in Patients With Chronic Kidney Disease - Medscape - Oct 01, 2007.