Room-temperature Storage of Medications Labeled for Refrigeration

Victor Cohen; Samantha P. Jellinek; Leftherios Teperikidis; Elliot Berkovits; William M. Goldman

Disclosures

Am J Health Syst Pharm. 2007;64(16):1711-1715. 

In This Article

Discussion

The table is limited by our hospital pharmacy's formulary; however, our purpose was to update the current literature.

The table is intended for use as a guide when medications labeled for refrigerated storage are inadvertently exposed to room-temperature. This may occur during routine excursions, power outages, compressor failures, natural disasters, and inadvertent storage at room-temperature if the need for refrigeration is unknown. According to the manufacturers surveyed, the medications included in the table may be returned to the refrigerator within the time period listed without affecting stability or expiration date. This table may help to avoid unnecessary drug loss and expenditures due to improper storage temperatures.

Although a full discussion of methods of stability information is beyond the scope of this article, the methods to evaluate temperature-related storage recommendations for medications are required to be reported to the Food and Drug Administration as part of current good manufacturing practices.

While recommended temperature-related storage data were easily retrievable from the medications' prescribing information, the effects of temporary excursions from refrigeration were not always addressed. Retrieving this information from each manufacturer was complicated by prolonged response times, lack of available data, and the inability of some manufacturers to release the information for legal reasons.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....