Tumor Necrosis Factor Alfa Antagonists for Pediatric Immune-Mediated Diseases

Marcia L. Buck, Pharm.D., FCCP

Pediatr Pharm. 2007;13(8):1-4. 

In This Article

Availability and Cost

Infliximab (Remicade®; Centocor) is available in 100 mg single-use vials. The contents must be reconstituted with sterile water and then diluted with normal saline to a final concentration between 0.4 and 4 mg/mL. Etanercept (Enbrel®; Immunex/Amgen) is available in pre-filled syringes and autoinjectors (50 mg/mL), as well as a 25 mg/mL multi-use vial. When reconstituted with sterile bacteriostatic water, the vial can be used for up to 14 days. Adalimumab (Humira®; Abbott) is available in 40 mg/0.8 mL pre-filled syringes and pens. All of these products must be refrigerated.[3,4,5,6,7,8]

As with other immunobiologic therapies, the TNFα antagonists cost substantially more than traditional therapies. The average wholesale price of a vial of infliximab is $670, while a one month supply of etanercept (4 doses) or adalimumab (2 doses) is approximately $1,500.[17]

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