Hypoxia and Hepatocellular Carcinoma: The Therapeutic Target for Hepatocellular Carcinoma

Xiong-Zhi Wu; Guang-Ru Xie; Dan Chen


J Gastroenterol Hepatol. 2007;22(8):1178-1182. 

In This Article

Hypoxia, Chemoresistance, and Radioresistance

Hypoxia in tumors is generally associated with chemoresistance and radioresistance.[38,39] Apoptosis of HIF-1α-transfected cells is inhibited when they are exposed to 5-Fu.[40] Hypoxia protects HepG2 cells against etoposide-induced apoptosis by inducing the expression of AP-1.[41] Moreover, the expression of multidrug resistance-related genes mdr1, multidrug resistance transporter P-glycoprotein, and lung resistance protein in HCC is under the control of HIF-1.[40,42] Thus, hypoxia induces multidrug resistance in HCC via hypoxia-elicited multidrug resistance related protein. Furthermore, hypoxia and HIF-1 promote the expression of genes which increase radioresistance in HCC.[43]


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