Antiplatelet Therapy in Patients with Unstable Angina and Non-ST-Segment-Elevation Myocardial Infarction: Findings from the CRUSADE National Quality Improvement Initiative

Michael B. Bottorff, Pharm.D.; Edith A. Nutescu, Pharm.D.; Sarah Spinler, Pharm.D.


Pharmacotherapy. 2007;27(8):1145-1152. 

In This Article


The ACC-AHA guidelines for management of unstable angina−NSTEMI provide clinicians with treatment recommendations derived from evidence-based clinical practice and expert opinion. Unfortunately, adherence to these guidelines, which is directly associated with improved patient care and reduced mortality rates, is suboptimal. The CRUSADE national quality improvement initiative strives to improve adherence and promote the guideline recommendations. Data from the CRUSADE initiative identified the many reasons why drugs such as aspirin, glycoprotein IIb-IIIa inhibitors, and clopidogrel are underutilized. This initiative and other quality improvement programs have shown that pharmacists can help overcome the barriers by interacting and educating other health care providers and patients.


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