Severe Cutaneous Adverse Reactions to Drugs

Faith L. Chia; Khai Pang Leong


Curr Opin Allergy Clin Immunol. 2007;7(4):304-309. 

In This Article

Treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Patients with HIV/AIDS

The advent of HIV/AIDS brings new challenges to the allergist. These patients are treated with multiple agents that can lead to the development of SJS/TENS, including antituberculosis drugs, antiretroviral therapy (especially nevirapine and abacavir) and sulfonamides (trimethoprim-sulfamethoxazole and dapsone). HIV positivity is itself a risk factor for serious cutaneous reactions due to antituberculosis therapy, increasing the odds by 3.8 times.[59] It is possible that HIV-positive patients with SJS or TEN may have a poorer outcome.[40]


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