Evidence That Two Alkyl Ester Quaternary Ammonium Compounds Lack Substantial Human Skin-Sensitizing Potential

Ian R. Jowsey; Albert M. Kligman; Ian R. White; An Goossens; David A. Basketter


Dermatitis. 2007;18(1):32-39. 

In This Article


The dialkyl ester of triethanol ammonium methyl sulphate (Chemical Abstracts Service [CAS] number 91-995-81-2) was obtained as Stepantex VRH90 (Stepan Co., Northfield, IL), which was found to be 85.5% TEA-Quat. The di-(hardened tallow fatty acid) ester of 2,3-dihydroxypropyl-trimethyl ammonium chloride (CAS 19467-38-0) was synthesized and was found to be approximately 83% HEQ. Both materials were stored under ambient conditions before being made up at the required concentrations in either distilled water or petrolatum.


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