Varenicline: The Newest Agent for Smoking Cessation

Lisa A. Potts; Candice L. Garwood

Disclosures

Am J Health Syst Pharm. 2007;64(13):1381-1384. 

In This Article

Safety

Varenicline is generally well tolerated. Mild to moderate nausea and vomiting are the most common adverse effects, occurring in approximately 30% of patients.[10] Dropout rates due to adverse events in the two bupropion comparison studies were 10.5% and 8.6% for varenicline, 12.6% and 15.2% for bupropion, and 7.3% and 9% for placebo.[12,13] Other common adverse effects observed in over 10% of participants included headache, insomnia, and abnormal dreams. Adjusting the dosage over one week and taking it after a meal with a full glass of water helped to decrease these effects.[8,10,14] There are currently no known contraindications to varenicline therapy.[10]

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