Inadequate Cerebral Oxygen Delivery and Central Fatigue during Strenuous Exercise

Lars Nybo; Peter Rasmussen


Exerc Sport Sci Rev. 2007;35(3):110-118. 

In This Article


In summary, strenuous exercise conditions that cause hyperventilation-induced restrictions of CBF may compromise oxygen delivery to active brain areas and lower the cerebral Pmito, but reductions in cerebral oxygenation become relevant for the development of central fatigue primarily when arterial hypoxemia is superimposed. Under such conditions, the mitochondrial oxygen tension may decline by more than 10 mm Hg as compared with rest, and it is no longer adequate to support the cerebral metabolism and maintain motor function.

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