The Cerebellum and Migraine

Maurice Vincent, MD, PhD; Nouchine Hadjikhani, MD


Headache. 2007;47(6):820-833. 

In This Article

Structural Changes in the Cerebellum and Migraine

Few studies have specifically addressed cerebellar structural changes in migraine. Dichgans et al found Magnetic Resonance Spectroscopy (1H-MRS) abnormalities in FHM-1 with reduced N-acetyl-aspartate (NAA), glutamate and elevated myo-inositol (mI) in the cerebellum, compatible with neuronal damage. Increased pH in the cerebrum and cerebellum, which normalized following acetazolamide treatment, as well as high lactate peak in half of the subjects has been reported in EA-2 patients.[145] Autopsy studies have shown pathological abnormalities in SCA including mild atrophy of the cerebellar folia, reduced number of Purkinje cells especially in the vermis, swelling of the Purkinje cell axons, decrease in granular cells, reduced number of dendrites in the molecular layers of Purkinje cells, and cerebellar cortical degeneration with reduced thickness of the molecular layer.[100,146] In FHM, cerebellar vermis atrophy and cortical cerebellar degeneration accompanied with Bergman glia proliferation have been described.[147]


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