Christine Yeh Hachem, MD; Hala El-Zimaity, MD Series Editor: Richard Goodgame, MD


September 27, 2007

Gastric Histology

Biopsies were taken of gastric mucosa and the polypoid lesions. Figures 11 through 13 are representative of the gastric mucosa, and Figures 14 and 15 are representative of the polypoid lesions.

Figure 11.

A low-power view of the gastric body. There is profound separation of the deep gastric glands (atrophy).

Figure 12.

A higher-power view of the same area seen in Figure 11. Lymphocytes are present between the glands, and numerous lymphocytes are in the surface epithelium and epithelial cells of the deeper glands.

Figure 13.

The biopsy from the gastric body is stained with the T-cell stain CD3. The intraepithelial lymphocytes are staining positive because they are T cells.

Figure 14.

This biopsy is from one of the polyps. It shows foveolar hyperplasia.

Figure 15.

A higher-power view of the polypoid lesion shown in Figure 14 reveals numerous intraepithelial lymphocytes in the polypoid lesion.

Diagnostic Question

2. On the basis of the gastric histology seen in Figures 11 through 15 and the previous discussion regarding differential diagnosis, which of the following is your final diagnosis?

View the correct answer.


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