Acinetobacter Pneumonia: A Review

Joshua D. Hartzell, MD, Andrew S. Kim, MD, Mark G. Kortepeter, MD, MPH, Kimberly A. Moran, MD

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Mortality

There is debate in the literature on the impact of Acinetobacter species infection on crude and attributable mortality.[11,94,95] A recent review and editorial highlighted the complexity surrounding this issue. In the editorial,[94] the authors cited a systematic review of 6 case-control studies of A baumannii infections, with an in-hospital and ICU attributable mortality of 7.8% to 23% and 10% to 43%, respectively. The authors concluded, however, that the heterogeneity of the studies precluded a definitive answer.[94]

Two more recent studies have been published. Investigators from Brooke Army Medical Center examined the effect of Abc infection on mortality in a cohort of burn patients.[96] Abc infection was associated with an increase in burn-related mortality in the univariate analysis but was no longer statistically significant in the multivariate analysis.

A retrospective, matched cohort study examined the mortality and length of hospital stay in patients infected with Acinetobacter.[97] Patients with multidrug-resistant Abc were compared with patients with susceptible Abc and those without Abc. A significant increase in length of both ICU and hospital stay was found in patients with multidrug-resistant Abc. There was a trend toward increased mortality but it failed to reach statistical significance after severity of illness was controlled for.

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