There is debate in the literature on the impact of Acinetobacter species infection on crude and attributable mortality.[11,94,95] A recent review and editorial highlighted the complexity surrounding this issue. In the editorial, the authors cited a systematic review of 6 case-control studies of A baumannii infections, with an in-hospital and ICU attributable mortality of 7.8% to 23% and 10% to 43%, respectively. The authors concluded, however, that the heterogeneity of the studies precluded a definitive answer.
Two more recent studies have been published. Investigators from Brooke Army Medical Center examined the effect of Abc infection on mortality in a cohort of burn patients. Abc infection was associated with an increase in burn-related mortality in the univariate analysis but was no longer statistically significant in the multivariate analysis.
A retrospective, matched cohort study examined the mortality and length of hospital stay in patients infected with Acinetobacter. Patients with multidrug-resistant Abc were compared with patients with susceptible Abc and those without Abc. A significant increase in length of both ICU and hospital stay was found in patients with multidrug-resistant Abc. There was a trend toward increased mortality but it failed to reach statistical significance after severity of illness was controlled for.
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Cite this: Acinetobacter Pneumonia: A Review - Medscape - Jul 05, 2007.