Acinetobacter Pneumonia: A Review

Joshua D. Hartzell, MD, Andrew S. Kim, MD, Mark G. Kortepeter, MD, MPH, Kimberly A. Moran, MD

In This Article


There is debate in the literature on the impact of Acinetobacter species infection on crude and attributable mortality.[11,94,95] A recent review and editorial highlighted the complexity surrounding this issue. In the editorial,[94] the authors cited a systematic review of 6 case-control studies of A baumannii infections, with an in-hospital and ICU attributable mortality of 7.8% to 23% and 10% to 43%, respectively. The authors concluded, however, that the heterogeneity of the studies precluded a definitive answer.[94]

Two more recent studies have been published. Investigators from Brooke Army Medical Center examined the effect of Abc infection on mortality in a cohort of burn patients.[96] Abc infection was associated with an increase in burn-related mortality in the univariate analysis but was no longer statistically significant in the multivariate analysis.

A retrospective, matched cohort study examined the mortality and length of hospital stay in patients infected with Acinetobacter.[97] Patients with multidrug-resistant Abc were compared with patients with susceptible Abc and those without Abc. A significant increase in length of both ICU and hospital stay was found in patients with multidrug-resistant Abc. There was a trend toward increased mortality but it failed to reach statistical significance after severity of illness was controlled for.


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