Acinetobacter Pneumonia: A Review

Joshua D. Hartzell, MD, Andrew S. Kim, MD, Mark G. Kortepeter, MD, MPH, Kimberly A. Moran, MD

In This Article


Abc remains an opportunistic pathogen that typically causes serious infection in immune-compromised hosts. The organism is encapsulated and has a cell wall containing lipopolysaccharides, but the effect of the lipopolysaccharides in humans is not well-understood.[42] There are few published studies that have examined the potential virulence factors of Abc. It is likely that several factors contribute to the transition from colonizer to invasive bacteria.

A recent review by Jolly-Guillou described the current literature regarding this topic.[42] One highlighted virulence factor was exopolysaccharide production, which is known to protect bacteria from the host's immune response.[42,43] Thirty percent of Abc strains produce exopolysaccharides, and studies in mice have demonstrated that strains producing exopolysaccharides are more virulent than nonproducing strains.[42,43] However, their role in human infection remains unknown.


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