Current Concepts in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Nahum Méndez-Sánchez; Marco Arrese; Daniel Zamora-Valdés; Misael Uribe


Liver International. 2007;27(4):423-433. 

In This Article


NAFLD is currently the commonest cause for elevated liver enzymes in clinical practice. Its pathophysiology is complex but insulin resistance seems to be critical in both its development and progression. Future prospects of therapy are based on a better knowledge of NAFLD pathophysiology, particularly on the role of oxidative stress and certain adipokines such as TNF-α and adiponectin. Finally, given the epidemic nature of NAFLD and its close association with obesity and metabolic syndrome, large-scale and integrated health interventions are advisable aiming to promote lifestyle changes among the general population and particularly in children and adolescents. This would surely impact on the NAFLD-related disease's burden in the near future.

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