Safety of Newer Antidepressants in Pregnancy

Cynthia M. Way, B.Sc.Pharm.


Pharmacotherapy. 2007;27(4):546-552. 

In This Article


Many factors should be considered when deciding on appropriate management of depression in pregnancy, including the severity of the depression and the preferences of the mother. There is a fair amount of information available for and experience with most SSRIs, especially fluoxetine. Clinicians and patients may want to avoid the use of paroxetine during pregnancy where clinical circumstances permit. Information on the use of venlafaxine, bupropion, and mirtazapine in pregnancy is limited. It may be prudent to carefully observe babies exposed to any antidepressant near term and monitor for signs or symptoms of a neonatal withdrawal syndrome.


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