[Case Study] A Case of Hyponatremia Caused by Central Hypocortisolism

Gabriele Parenti; Valdo Ricca; Alessia Zogheri; Mario Serio; Massimo Mannelli; Alessandro Peri*


Nat Clin Pract Endocrinol Metab. 2007;3(4):369-375. 

In This Article


We reported the complex case of a 43-year-old woman with severe depression exacerbated by hyponatremia. The diagnostic work-up carried out illustrates the importance of identifying the etiology of an electrolyte imbalance in order to start the most appropriate treatment. We suggest that hypocortisolism should always be taken into consideration as a possible diagnosis in patients with normovolemic hyponatremia who have severe depression.

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