Sidebar: Key Points
Ramelteon acts as an MT1 and MT2 melatonin receptor agonist, showing higher affinities for these receptors than does the natural ligand
Ramelteon induces sleep initiation and maintenance, as demonstrated in animal models and clinical trials
Ramelteon is efficient in treating chronic insomnia, without causing addiction, hangover or withdrawal effects
Ramelteon is assumed to promote sleep efficacy by influencing homeostatic as well as chronobiotic sleep regulation
A major metabolite of ramelteon, which accumulates to levels 10-fold higher than the parent drug, contributes to the drug's effects
Safety of ramelteon seems to be sufficient after short-term administration, but long-term treatment of elderly or unwell individuals requires further study
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Seithikurippu R Pandi-Perumal, Comprehensive Center for Sleep Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, 1176 5th Avenue, New York, NY 10029. Email: firstname.lastname@example.org .
Nat Clin Pract Neurol. 2007;3(4):221-228. © 2007 Nature Publishing Group
Cite this: Drug Insight: The Use of Melatonergic Agonists for the Treatment of Insomnia -- Focus on Ramelteon - Medscape - Apr 01, 2007.