Systemic Therapy for Rosacea

H. E. Baldwin, MD


Skin Therapy Letter. 2007;12(2) 

In This Article


Until recently, there had been little change in the systemic treatment options for rosacea over the last several decades. In 2007, more aggressive and innovative uses of existing oral agents have resulted in novel therapeutic approaches. The development of anti-inflammatory dose doxycycline monohydrate is an intriguing alternative to long-term or episodic use of full-dose antibiotics. Once-daily dosing with the controlled-release formulation of doxycycline monohydrate can be expected to improve compliance and therefore efficacy. Furthermore, anti-inflammatory dose doxycycline and isotretinoin are helpful modalities for preventing treatment failures. Agents with good or acceptable safety profiles allow for long-term therapy and provide sustained remission. More importantly, the use of oral agents that do not increase the likelihood of future bacterial resistance is of global importance.


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