Predicting Persistent/Recurrent Disease in the Cervix After Excisional Biopsy

Sanjay M. Ramchandani, MD; Karen L. Houck, MD; Enrique Hernandez, MD; John P. Gaughan, PhD

In This Article


There is controversy as to which factors are most predictive of persistent or recurrent disease after cervical cold knife conization or loop electrosurgical excision procedure (LEEP).[1,2,3,4,5,6,7,8,9,10,11] There is a lack of agreement on the usefulness of performing an endocervical curettage (ECC) at the time of excisional biopsy of the cervix and the ability of the ECC to help predict persistent disease above the site of excision.[12,13,14,15,16] Recommendations for the clinical management of patients after conization are based on the histopathologic findings, the status of the surgical margin, patient's age and parity, patient's desire for future fertility, and concomitant upper genital tract pathology.

This retrospective observational study explored the ability of various factors to predict persistent/recurrent disease after a conization, with special attention to the ECC.


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