Dietary Factors in the Modulation of Inflammatory Bowel Disease Activity

Shinil Shah, DO, PGY-1


March 27, 2007

Wheatgrass Juice

Wheatgrass juice has been investigated as a possible therapy for ulcerative colitis. The components of wheatgrass juice include chlorophyll; vitamins A, C, and E; and various amino acids. It has been demonstrated that wheatgrass juice is anti-mutagenic. One constituent of wheatgrass is apigenin, which is believed to possess both anti-inflammatory and antioxidant properties. Some believe that this constituent may be beneficial in ulcerative colitis.[42,44] It is a bioflavonoid that has been shown to inhibit TNF-induced transactivation.[43]

A randomized controlled trial of wheatgrass juice in the management of ulcerative colitis has demonstrated some efficacy. While sigmoidoscopic evaluation failed to demonstrate a statistically significant difference between the treatment and control group, it was demonstrated that there was a significant difference in other symptomatic indicators of disease activity, such as rectal bleeding. Although there was not a statistically significant difference in relation to sigmoidoscopic evaluation, 78% of the treatment group improved compared to 30% of the control group.[44]


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.